Figure 2
ARPA using dbGaP data reconstructed a tree resembling the tree generated during the exploratory phase with the Mexican-American MDD sample in Figure 1. Most of the genes involved in the branching process, that is, PDE6C, PSMD9, HSD3B1, BDNF and PDLIM5, were replicated. This tree has one gene (GHRHR) not present in the exploratory tree. Reconstruction of the tree highlighted that some covariates used by the multidimensional phenotype, that is, nicotine and alcohol use, provided a significant weight to the process of discriminating MDD-affected individuals from unaffected during the branching. For easier understanding, Figure 1 tree is reproduced in the right upper corner inset and genes in the two trees are color-coordinated.
