Figure 1
From: Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11
p11KO mice display memory impairments and atypical pharmacological responses to 5-HT1BR stimulation. Schematic setup of the passive avoidance procedure (a). At training, a mouse explores a bright compartment for 60 s. After door opening, time is measured for the mouse to enter the dark compartment (training latency). Upon step-though, the unconditioned stimulus (US) (0.3 mA, 2 s scrambled current) is delivered. Following a 5 min or 24 h delay, the step-through latency to return to the dark compartment is measured (retention latency). Step-through latencies of mice at training (b) and at the short-term (5 min) or long-term (24 h) (c) memory test. Learning-related avoidance was present in all groups if tested after 5 min, but only in WT after 24 h (c). Reduced training latencies (d) and switched responses to the 5-HT1BR agonist CP94253 (CP) in P11KO on emotional memory function (e). Learning-related avoidance was induced in all groups except for WT CP94253 and P11KO vehicle (e). n=5–13 (b–c), 10–19 (d–e) mice per group. ++P<0.01; +++P<0.001 indicates significant difference between training and testing performances. Data are presented as means±s.e.m. CP: CP94253 (5-HT1BR agonist), P11KO: p11 knock-out mice, H and HET: p11heterozygous mice, WT: wild type mice, G: genotype, Veh: vehicle. *P<0.05; **P<0.01; ***P<0.001; #P<0.05; ##P<0.01.
