Figure 3

Pharmacogenetic analyses: three subjects in the GSK1521498 5 mg day−1 group with one or more copies of the 118 G allele (AG) were compared with A118 homozygotes (AA, N=12). The left panel depicts the mean weight change over the treatment period and the right panel displays the individual weight plots for all 15 Caucasian subjects. It can be seen that greatest weight change is seen in two of the G-carriers (AG). ***P<0.001.