Table 5 Reproducibility between independent GWAS

From: Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction

Numbers and overlap across studies

ISC

GAIN EA

GAIN AA

ISC vs GAIN EA

ISC vs GAIN AA

GAIN EA vs GAIN AA

ISC vs. GAIN-EA vs. GAIN-AA (% of ISC)

SNPs Pâ©˝0.05

45 972

42 336

57 118

2649

2986

2839

163 (0.4%)

Genes

10 180

9002

11 260

6470

7583

6807

5518 (54.2%)

Genes CFG â©ľ1

3194

2913

3524

2243

2564

2384

2012 (63.0%)

Genes CFG â©ľ3

186

173

201

147

160

153

134 (72.0%)

Genes CFG â©ľ4

42

41

45

37

37

38

35 (83.3%)

Pathways for genes with CFG â©ľ1

217

210

205

194

188

180

176 (81.1%)

Pathways for genes with CFG â©ľ3

79

85

108

72

76

81

72 (91.1%)

Pathways for genes with CFG â©ľ4

34

50

75

33

34

48

33 (97.1%)

  1. Abbreviations: AA, African American; CFG, convergent functional genomics; EA, European American; GWAS, genome-wide association study; ISC, International Schizophrenia Consortium; SNP, single-nucleotide polymorphism.
  2. Increasing consistency and overlap observed from nominally significant SNPs (0.4%) to genes, then to CFG prioritized genes, and finally to pathways of CFG prioritized genes (97.1%).
Back to article page