Figure 1 | Molecular Psychiatry

Figure 1

From: Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease

Figure 1

Pooling/bootstrap genome-wide association study (pbGWAS) strategy when considering n1=n2=96 cases and controls. After generating a total of k pairs of randomplates (steps) by bootstrapping DNA samples, m SNPs (single-nucleotide polymorphisms) are tested on pooled samples at each step. Results from pairs 1 to k is combined using meta-analytical methods.

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