Table 1 Meta-analytic results for the 30 most predictive SNPs in the Skafidas classifier

From: Response to ‘Predicting the diagnosis of autism spectrum disorder using gene pathway analysis’

SNP

Chr

BP

A1

A2

ln(OR)

P-value

rs260808

11

103 909 166

A

C

−0.024

0.510

rs769052

5

138 944 433

T

C

−0.042

0.422

rs876619

16

56 283 534

A

C

0.044

0.398

rs905646

11

88 353 802

A

G

0.062

0.167

rs968122

12

70 791 615

T

C

0.001

0.974

rs984371

11

55 577 698

T

C

0.018

0.594

rs1243679

14

21 093 733

A

G

0.027

0.710

rs1818106

11

103 913 376

A

C

0.009

0.736

rs2239118

12

2 660 753

T

C

0.054

0.097

rs2240228

19

15 852 872

A

G

0.083

0.007

rs2300497

14

90 865 283

T

C

0.034

0.408

rs2384061

2

25 135 620

A

G

0.052

0.058

rs3773540

3

55 096 928

A

G

−0.085

0.273

rs4128941

17

63 531 331

A

G

−0.123

0.085

rs4308342

4

71 884 205

T

G

−0.107

0.142

rs4648135

4

103 536 670

A

G

0.008

0.894

rs6483362

11

88 412 451

A

G

−0.0335

0.513

rs7313997

12

71 265 958

A

C

0.035

0.450

rs7562445

2

213 192 048

T

G

0.042

0.279

rs7842798

8

131 890 170

A

G

0.033

0.241

rs8053370

16

56 262 906

T

C

−0.042

0.415

rs9288685

2

233 987 114

T

C

−0.007

0.804

rs10193128

2

233 987 722

T

C

−0.015

0.581

rs10409541

19

13 433 127

T

C

0.087

0.048

rs11020772

12

70 792 582

T

G

0.001

0.966

rs11145506

9

80 264 584

T

C

−0.117

0.282

rs12317962

12

70 792 582

T

G

0.001

0.966

rs12582971

12

18 459 387

T

C

−0.001

0.981

rs17629494

10

53 560 898

T

C

−0.060

0.217

rs17643974

10

126 792 798

T

C

0.002

0.964

  1. Abbreviations: BP, base pair in HG19; Chr, chromosome; OR, odds ratio; SNP, single-nucleotide polymorphism.
  2. The SNP name, chromosome, base pair, reference allele, alternate allele, natural log of the odds ratio and P-value are presented from the meta-analysis of autism spectrum disorders from the Psychiatric Genomics Consortium. This meta-analytic strategy reflects the weighted combination of the contributing cohorts reflective of power to detect association. None of the SNPs meet a multiple testing significance threshold, let alone the genome-wide association threshold of 5 × 10−8.