Figure 2
Electroencephalography (EEG) effects of lanicemine relative to ketamine in man. Left: Distribution over skull surface of absolute gamma EEG magnitude, theta-cordance and alpha slow-wave index at 1 h of perfusion. Color mapping depicts levels of statistical significance between study drug (lanicemine 75 or 150 mg; ketamine 0.5 mg kg−1) and vehicle at a given electrode location (blue: decrease; red: increase in P-value). Top right: Comparison of lanicemine (75 or 150 mg), ketamine (0.5 mg kg−1), and vehicle for mean (s.e.) change in relative gamma-EEG magnitude over time (eyes closed). Bottom right: Comparison of lanicemine (75 or 150 mg), ketamine (0.5 mg kg−1), and vehicle for mean (s.e.) change in Clinician Administered Dissociative States Scale (CADSS) total score from baseline. CADSS total score was increased significantly with ketamine vs vehicle at 1 h (P<0.01) and across all times (P<0.05). Lanicemine (each dose) did not significantly increase CADSS total score vs vehicle at any time.
