Table 1 Frequencies of 22q11.2 duplications in cases and controls
From: Evidence that duplications of 22q11.2 protect against schizophrenia
Study | Case 22q11.2dup frequency (N CNVs/N samples) | Control 22q11.2dup frequency (N CNVs/N samples) | P value (Fisher's exact test) | OR (95% CI) |
|---|---|---|---|---|
Discovery | 0% (0/6 882) | 0.089% (10/11 255) | 0.017 (2-Tail) | |
Replication | ||||
MGS EA | 0.090% (2/2 215) | 0.16% (4/2 556) | ||
MGS AA | 0% (0/977) | 0.23% (2/881) | ||
ISC | 0% (0/3 395) | 0.031% (1/3 185) | ||
Irish/WTCCC2 | 0% (0/1 377) | 0.10% (1/992) | ||
African American | 0.061% (1/1 637) | 0% (0/960) | ||
Swedish | 0% (0/4 655) | 0.066% (4/6 038) | ||
Total replication | 0.021% (3/14 256) | 0.082% (12/14 612) | 0.020 (1-Tail) | |
Total discovery+replication | 0.014% (3/21 138) | 0.085% (22/25 867) | 0.00086 (2-Tail) | 0.17 (0.050–0.56) |
Other disorders | ||||
ID/DD/CM | 0.32% (50/15 767) | 0.085% (23/27 133) | 5.9 × 10–8 (2-Tail) | 3.75 (2.29–6.15) |
ASD | 0.28% (12/4 315) | 0.085% (23/27 133) | 0.002 (2-Tail) | 3.29 (1.63–6.61) |
