Table 4 IFN α/β signaling pathway genes with the strongest associations with MDD

From: Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing

Gene Name

P-value

Rank among all genes

Direction

MX1

1.26E-04

7

+

OAS1

2.52E-04

15

+

IFIT3

3.78E-04

22

+

PTPN6

1.26E-03

43

+

ADAR

1.26E-03

45

+

IRF7

1.64E-03

53

+

IFIT1

3.15E-03

100

+

USP18

3.78E-03

121

+

ISG15

3.78E-03

122

+

OAS2

4.16E-03

127

+

IRF8

6.93E-03

185

+

IFIT2

7.30E-03

201

+

OAS3

7.56E-03

208

+

MX2

8.44E-03

226

+

IRF9

1.07E-02

274

+

IFI6

1.13E-02

285

+

OASL

1.44E-02

352

+

XAF1

1.49E-02

362

+

IFI35

1.65E-02

404

+

IFNAR2

4.99E-02

1030

−

  1. The table shows the top twenty genes (those associated with nominal P-value<0.05) in the interferon α/β signaling pathway, along with P-values, direction of effect, and association rank among all expressed genes.
Back to article page