Table 1 Conditional FDR<0.05, non MHC SNPs associated with schizophrenia given multiple sclerosis

From: Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci

Locus #

SNP

Location

Gene

SCZ P

FDR SCZ

FDR SCZ|MS

1

rs1625579

1p21.3

AK094607 a, b (MIR137HG)

5.52E-06

4.92E-02

3.69E-02

2

rs17180327

2q31.3

CWC22 b, c

6.37E-06

5.19E-02

3.95E-03

3

rs7646226

3p21-p14

PTPRG b, c

5.51E-06

4.92E-02

2.43E-02

4

rs9462875

6p21.1

CUL9 b, c

1.20E-05

6.59E-02

4.14E-02

5

rs10257990

7p22

MAD1L1 a, b

5.53E-06

4.92E-02

1.63E-02

6

rs10503253

8p23.2

CSMD1 a, b

3.96E-06

4.70E-02

4.04E-02

 

rs10503256

8p23.2

CSMD1 a, b

2.27E-06

4.32E-02

1.29E-02

7

rs6990941

8q21.3

MMP16 a, b

2.48E-06

4.32E-02

1.48E-02

8

rs396861

9p24

AK3

6.89E-06

5.19E-02

4.53E-02

9

rs4532960

10q24.32

AS3MT b

2.65E-06

4.32E-02

1.29E-02

10

rs12411886

10q24.32

CNNM2 a, b

1.79E-06

4.10E-02

1.86E-02

11

rs11191732

10q25.1

NEURL b

2.55E-06

4.32E-02

2.69E-02

12

rs1025641

10q26.2

C10orf90

7.51E-06

5.54E-02

4.87E-02

13

rs2852034

11q22.1

CNTN5

1.12E-05

6.00E-02

2.90E-02

14

rs540723

11q23.3

STT3A b

1.82E-06

4.10E-02

2.56E-02

15

rs7972947

12p13.3

CACNA1C a, b

7.12E-06

5.54E-02

4.87E-02

16

rs2007044

12p13.3

CACNA1C a, b

2.74E-05

9.43E-02

1.75E-02

17

rs12436216

14q13.2

KIAA0391 b

7.40E-06

5.54E-02

4.87E-02

18

rs1869901

15q15

PLCB2 b

3.66E-06

4.70E-02

4.04E-02

19

rs4887348

15q25

NTRK3

4.69E-05

1.39E-01

3.05E-02

20

rs4309482

18

AK093940

9.66E-06

6.00E-02

1.34E-02

  1. Independent complex or single-gene loci (r2<0.2) with SNP(s) with a conditional FDR (SCZ|MS)<0.05 in schizophrenia (SCZ) given association in multiple sclerosis (MS). All significant SNPs are listed and sorted in each LD block and independent loci are listed consecutively (Locus #). Chromosome location (Location), closest gene (Gene), P-value of SCZ (SCZ P-value) and false discovery rate of SCZ, FDR (SCZ) are also listed. All data were first corrected for genomic inflation.
  2. aLoci identified by GWASs without leveraging genetic pleiotropy structure between phenotypes.
  3. bLoci identified using conditional FDR method on SCZ with CVD.
  4. cLoci identified using conditional FDR method on SCZ with BD.