Figure 2
(a) Manhattan plot of region-wise association analysis. The blue line indicates genome-wide significance (P=9.0 × 10−7). (b) Regional association plot of rs3123688 located upstream of ZEB1. The P-values in green are from the genome-wide association (GWA) analysis and P-values marked in blue are from the combined analysis of Danish individuals. The vertical lines represent the region-wise P-values. The linkage disequilibrium (LD; r2) between the single nucleotide polymorphism in focus and its flanking markers genotyped in the GWA study are demonstrated in red (high LD) to white (low LD). The recombination rate is plotted in blue according to HapMap (CEU).
