Table 1 The top 50 differentially methylated CpG sites identified in ASD-discordant MZ twin pairs, ranked by statistical significance and mean Δβ (calculated as DNA methylation level of ASD twin minus well twin)

From: Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits

Rank	ProbeID	Gene	Chr.	Position	Mean Δβ	P-value
1	cg13735974	NFYC	1	4092 9567	0.08	3.63E−04
2	cg27321538	DNPEP	2	2 1996 0475	0.05	1.33E−03
3	cg01447498	TSNAX	1	22 9731 294	0.05	9.68E−04
4	cg08142684	TCP1	6	160 129 858	−0.06	4.29E−03
5	cg11241627	FERD3L	7	19 151 690	−0.07	4.74E−03
6	cg20372689	RCN2	15	75 010 774	0.05	2.08E−03
7	cg21195120	MBTPS2	X	21 768 225	−0.05	3.47E−03
8	cg04689061	PKIA	8	79 590 548	0.08	6.55E−03
9	cg21614638	DAPP1	4	100 956 844	0.05	3.48E−03
10	cg02639007	CCDC41	12	93 377 476	0.05	4.90E−03
11	cg15700739	HOXC5	12	52 713 967	0.04	8.79E−04
12	cg12148581	RPL14	3	40 473 347	0.05	6.67E−03
13	cg25118574	PSMB7	9	126 217 467	0.05	5.09E−03
14	cg06284322	TAF7	5	140 680 846	−0.05	7.30E−03
15	cg23397015	INHBB	2	120 818 902	−0.05	8.95E−03
16	cg12241297	HNRPA0	5	137 118 306	0.05	9.57E−03
17	cg13588354	MC3R	20	54 256 710	0.04	4.27E−03
18	cg10528989	BDKRB1	14	95 792 059	0.04	5.48E−03
19	cg15836394	FDFT1	8	11 697 241	0.04	1.61E−03
20	cg21935083	RAD50	5	131 920 213	0.05	1.16E−02
21	cg03660451	RECQL5	17	71 176 201	−0.04	2.80E−03
22	cg16166399	ZNF499	19	63 722 565	0.06	1.30E−02
23	cg23627134	ARHGAP15	2	143 602 845	0.05	1.16E−02
24	cg05751148	PTPRCAP	11	66 961 375	0.04	3.48E−03
25	cg18284523	TINF2	14	23 781 402	0.04	8.23E−03
26	cg20346096	C18orf22	18	75 895 818	−0.04	1.96E−04
27	cg07200280	RAFTLIN	3	16 529 623	−0.04	3.34E−03
28	cg12624641	C14orf143	14	89 490 322	0.04	8.96E−03
29	cg01253545	RNF185	22	29 886 314	−0.06	1.48E−02
30	cg17367215	SUPT5H	19	44 628 460	−0.04	3.15E−03
31	cg01894895	ANXA1	9	74 956 114	−0.05	1.32E−02
32	cg24687764	C16orf46	16	79 668 575	−0.04	1.12E−02
33	cg20917484	GAPDH	12	6 514 327	−0.04	1.74E−03
34	cg18776056	FKBP4	12	2 775 173	−0.04	1.40E−03
35	cg19674669	LOC112937	11	133 652 120	0.04	2.91E−03
36	cg03875195	SLC30A3	2	27 339 867	−0.04	1.09E−02
37	cg05520656	ZNF681	19	23 733 431	0.04	8.51E−03
38	cg18515587	SELENBP1	1	149 611 430	0.04	6.46E−03
39	cg07239938	ELA2	19	803 813	0.04	9.48E−03
40	cg01148741	DUSP2	2	96 175 180	−0.05	1.40E−02
41	cg17002259	CDC42SE1	1	149 298 884	0.04	8.37E−03
42	cg02154186	PNMA2	8	26 427 270	−0.04	7.53E−03
43	cg18482268	POU4F3	5	145 699 158	−0.04	4.62E−03
44	cg20969846	DIDO1	20	61 040 666	0.04	4.34E−03
45	cg00347904	SCUBE3	6	35 290 486	−0.05	1.78E−02
46	cg26799474	CASP8	2	201 807 196	0.04	5.41E−03
47	cg07584959	THRAP5	19	843937	−0.04	1.44E−02
48	cg19235307	MBD4	3	130 642 844	−0.04	1.26E−02
49	cg11861730	ETS1	11	127 897 893	0.04	8.97E−03
50	cg21410991	ISL1	5	50 714 208	0.03	1.52E−03

Abbreviations: ASD, autism spectrum disorder; MZ, monozygotic.

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Table 1 The top 50 differentially methylated CpG sites identified in ASD-discordant MZ twin pairs, ranked by statistical significance and mean Δβ (calculated as DNA methylation level of ASD twin minus well twin)

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