Table 2 Differentially methylated loci highlighted from multiple analytic groups and their relevance to ASD phenotype

From: Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits

Associated phenotype

Reported in analyses

Gene

ASD

(1) Case versus control

(2) ASD-discordant twins

NFYC, PTPRCAP

 

(1) Sporadic versus familial ASD

(2) ASD-discordant twins

MBD4, RNF185, TINF2

Social autistic traits

(1) Discordant twins for social autistic traits

(2) Combined autism group

AFF2, GNB2, GRB2, MAP4, PDHX, PIK3C3, SMEK2, THEX1

Autistic RRBIs

(1) Discordant twins for RRBIs

(2) Combined discordant group

(3) ASD-discordant twins

TCP1

 

(1) Discordant twins for RRBIs

(2) Combined discordant group

ANKS1A, APXL, BPI, EFTUD2, NUDCD3, SNRPN, SOCS2

Communication autistic traits

(1) Discordant twins for communication autistic traits

(2) Case versus control

NUP43

 

(1) Discordant twins for communication autistic traits

(2) Combined discordant group

CCT6A, CEP55, FCJ12505, SRF

  1. Abbreviations: ASD, autism spectrum disorder; RRBI, restricted repetitive behaviours and interests.
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