Figure 1
(a) Top, sagittal and axial views: T-maps of comparisons between subthreshold bipolar (SBP) adolescents and controls superimposed on the average T1-weighted magnetic resonance imaging (MRI) of all IMAGEN database participants. Blue colour indicates white-matter tracts where fractional anisotropy (FA) is lower; red indicates tracts where radial diffusivity (RD) is higher (P<0.05 family-wise error corrected) in SBP adolescents; green indicates regions with lower gray-matter volume in SBP adolescents (P<0.001, uncorrected); white indicates white-matter skeleton. FA and RD images are displayed using the ‘tbss_fill’ script, which allows better visualization of the regions with significant between-group differences. (b) Three-dimensional representation using the Anatomist software (http://brainvisa.info); statistical maps are projected onto a single IMAGEN participant brain mesh. The same color code as above is in use.
