Table 2 Top gene expression biomarkers for suicidality

From: Discovery and validation of blood biomarkers for suicidality

Gene symbol /gene name

Probesets

Change

Differential expression score

Prior human genetic evidence

Prior human brain expression evidence

Total CFG score

SAT1

Spermidine/spermine N1–acetyltransferase 1

203455_s_at

I

2

(Association) Suicide attempt;45 suicide46

Suicide in depression

(D) PFC47

Suicide

(D) AMY, PFC, HIP, THAL39

Suicide

(D) PFC48

Suicide

(D) PFC49

Suicide

(D) PFC50

Suicide

(D) PFC51

Suicide

(D) PFC52

Suicide

(D) PFC46

8

CD24

CD24 molecule

209772_s_at

D

4

 

Suicide in mood disorders

(D) NAC15

8

FOXN3

Forkhead box N3

230790_x_at

I

2

(Association) Suicide53

Suicide (I) PFC53

8

GBP1

Guanylate binding protein 1, interferon-inducible, 67 kDa

231577_s_at

202269_x_at

202270_at

I

4

2

2

 

Suicide in mood disorders (D) NAC15

8

6

6

PIK3R5

Phosphoinositide-3-kinase, regulatory subunit 5

227553_at

I

4

 

Suicide in mood disorders (D) PFC15

8

APOL2

Apolipoprotein L2

221653_x_at

I

2

 

Suicide PFC (I)54

6

ATP13A2

ATPase type 13A2

218608_at

D

2

 

Suicide (D)15

6

ATP6V0E1

ATPase, H+ transporting, lysosomal 9 kDa, V0 subunit e1

214149_s_at 214244_s_at

I

2

 

Suicide (D) PFC46

6

EPHX1

Epoxide hydrolase 1, microsomal (xenobiotic)

202017_at

D

2

 

Suicide in schizophrenia

(D) PFC55

6

GCOM1

GRINL1A complex locus 1

239099_at

I

2

 

Suicide in depression (D) PFC56

6

HTRA1

HtrA serine peptidase 1

201185_at

D

2

 

Suicide (I)15

6

IL1B

Interleukin 1, beta

39402_at

I

2

 

Suicide (I) PFC57

6

LEPR

Leptin receptor

211354_s_at

D

2

 

Suicide

(D) PFC56

(D) PFC58

(D) HIP59

Suicide in depression (I) PFC60

6

LHFP

Lipoma HMGIC fusion partner

218656_s_at

I

2

 

Suicide in mood disorders

(I) NAC15

6

LIPA

Lipase A

236156_at

I

2

 

Violent suicide

(I) PFC61

6

MARCKS

Myristoylated alanine-rich protein kinase C substrate

213002_at

I

2

 

Suicide in depression (I)62

6

PGLS

6-Phosphogluconolactonase

230699_at

I

2

 

Suicide PFC (D)54

6

PTEN

Phosphatase and tensin homolog

222176_at

I

2

 

Suicide PFC, HIP (I)26

6

RECK

Reversion-inducing-cysteine-rich protein with kazal motifs

216153_x_at

I

2

 

Suicide (I) PFC15

6

SPTBN1

Spectrin, beta, non-erythrocytic 1

200671_s_at

D

2

 

Suicide in mood disorders

(I) NAC15

6

TNFSF10

Tumor necrosis factor (ligand) superfamily, member 10

202688_at 202687_s_at 214329_x_at

I

2

 

Suicide in schizophrenia

(I) PFC55

Suicide in depression (I) PFC60

6

ABCA1

ATP-binding cassette, subfamily A (ABC1), member 1

203504_s_at

I

4

  

4

ARHGEF40 (FLJ10357)

Rho guanine nucleotide exchange factor (GEF) 40

241631_at

I

4

  

4

CASC1

Cancer susceptibility candidate 1

220168_at

I

4

  

4

DHRS9

Dehydrogenase/reductase (SDR family) member 9

219799_s_at

I

4

  

4

DISC1

Disrupted in schizophrenia 1

244642_at

I

2

(Association) Suicide53

 

4

EIF2AK2

Eukaryotic translation initiation factor 2-alpha kinase 2

204211_x_at

I

4

  

4

LOC727820

Uncharacterized LOC727820

231247_s_at

I

4

  

4

MAP3K3

Mitogen-activated protein kinase kinase kinase 3

242117_at

I

4

  

4

MBNL2

Muscleblind-like 2 (Drosophila)

205017_s_at

D

2

(Association) Suicide53

 

4

MT-ND6 (ND6)

Mitochondrially encoded NADH dehydrogenase 6

1553575_at

I

4

  

4

OR2J3

Olfactory receptor, family 2, subfamily J, member 3

217334_at

D

4

  

4

RBM47

RNA binding motif protein 47

1565597_at

I

4

  

4

RHEB

Ras homolog enriched in brain

227633_at

D

2

(Association) Suicide63

 

4

RICTOR

RPTOR independent companion of MTOR, complex 2

228248_at

I

4

  

4

SAMD9L

Sterile alpha motif domain containing 9-like

243271_at; 230036_at

I

4

  

4

SCARF1

Scavenger receptor class F, member 1

206995_x_at

I

4

  

4

SLC36A1

Solute carrier family 36 (proton/amino acid symporter), member 1

213119_at

I

4

  

4

STAT1

Signal transducer and activator of transcription 1, 91kDa

232375_at

I

4

  

4

UBA6

Ubiquitin-like modifier activating enzyme 6

236879_at

I

4

  

4

ZC3HAV1

Zinc finger CCCH-type, antiviral 1

1563075_s_at

I

4

  

4

COX5B

Cytochrome c oxidase subunit Vb

213736_at

I

2

(Linkage) 2q11.264

 

3

SMARCA1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

203874_s_at

I

2

(Linkage) Xq2550

 

3

DBP

D-box binding protein

209782_s_at

D

2

  

2

  1. Abbreviations: I, increased in expression; D, decreased in expression; AMY, amygdala; PFC, prefrontal cortex; THAL, thalamus; HIP, hippocampus; NAC, nucleus accumbens.
  2. The underlined gene names have human genetic association evidence.
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