Figure 2
Gria1−/− mice display impaired short-term habituation on the spatial novelty preference test. During a 5-min Exposure phase (left panel), mice were allowed to explore two arms (Start and Other) of a 3-arm, Perspex Y-maze surrounded by distal extra-maze cues. After a 1-min delay, the mice were returned to the maze for the Test phase (2-min duration), during which they were now able to explore freely all three maze arms, including the previously unvisited (novel) arm (centre panel). Gria1 deletion impaired performance on the spatial novelty preference test. Wild-type (WT) mice exhibit a preference for the previously unvisited (Novel) arm over the two familiar arms to which they have previously been exposed (Start and Other). Gria1−/− mice did not show a significant preference for the novel arm. Ratio of time spent in the novel versus other arm (±s.e.m.). (Data from Sanderson et al.95). *P<0.05 difference between groups.
