Table 3 Cognitive and symptom outcomes in parallel groups analyses

Omnibus tests for measure x treatment x visit interaction		(M)ANOVA results			Placebo LSD comparisons			Raloxifene LSD comparisons
Measure	N	Test value	F-test	P-value	Mean difference (s.e.)	P-value	Cohen's d	Mean difference (s.e.)	P-value	Cohen's d
Cognitive outcomes
Cognitive tests: condition × time	79	W-L 0.9	(4,74)=2.7	0.04
WAIS-III-LNS	79	H-F 0.4	(1,78)=1.9	0.17	−0.2 (0.1)	0.03	0.23	−0.0 (0.1)	0.80	0.03
WMSR-LMI	79	H-F 2.2	(1,78)=4.2	0.04	−0.3 (0.2)	0.07	0.26	−0.8 (0.2)	<0.001^a	0.64
WMSR-LMII	79	H-F 1.4	(1,78)=2.2	0.14	−0.3 (0.2)	0.07	0.30	−0.7 (0.2)	<0.001^a	0.62
COWAT	79	H-F 1.1	(1,78)=4.6	0.03	0.2 (0.1)	0.08	0.21	−0.1 (0.1)	0.21	0.14
TMT-A: condition × time	57	W-L 0.9	(1,55)=6.0	0.02
TMT-A					0.1 (0.2)	0.77	0.05	0.7 (0.2)	<0.001^a	0.59
Symptom outcomes
PANSS tests: condition × time	79	W-L 1.0	(3,75)=0.7	0.54
Positive		−	−	−	1.2 (0.4)	<0.01	0.27	0.8 (0.4)	0.05	0.16
Negative		−	−	−	−0.0 (0.6)	0.96	0.00	0.9 (0.5)	0.11	0.17
General		−	−	−	1.8 (0.7)	0.01	0.22	2.0 (0.7)	<0.01	0.23
DASS tests: condition × time	78	W-L 1.0	(3,74)=1.1	0.35
Depression		−	−	−	1.1 (1.3)	0.39	0.11	2.9 (1.3)	0.03	0.34
Anxiety		−	−	−	0.8 (1.1)	0.47	0.11	1.3 (1.1)	0.24	0.21
Stress		−	−	−	2.2 (1.4)	0.11	0.24	0.9 (1.4)	0.52	0.11
SF-36v2 total: condition × time	77	W-L 1.0	(1,75)=0.0	0.84	−4.9 (2.1)	0.02	0.27	−4.3 (2.1)	0.04	0.24
SQLS total: condition × time	75	W-L 1.0	(1,73)=0.1	0.81	4.3 (2.2)	0.05	0.25	5.1 (2.1)	0.02	0.31

Abbreviations: COWAT, Controlled Oral Word Association Test; DASS, depression anxiety and stress scale; H-F, Huynh-Feldt value; LSD, least significant difference; PANSS, positive and negative syndrome scale; SF-36v2, short form 36 version 2 health survey questionnaire; SQLS, Schizophrenia Quality of Life Scale; TMT-A, Trail Making Test A; W-L, Wilk's Lamda; WAIS-III-LNS, Wechsler Adult Intelligence scale 3rd Edition letter number sequencing; WMSR-LMI, Wechsler Memory Scale Revised Logical Memory I; WMSR-LMII, Wechsler Memory Scale Revised Logical Memory II.
^aSignificant after Holm–Bonferroni correction.
Cohen's d calculated as (mean difference)/(s.d. pooled). Cognitive z-scores were used for cognitive analyses.
Mean difference reflects the change from baseline to 6 weeks for each condition, where a negative value is an improvement for LNS, LMI, LMII, COWAT and SF-36v2 and a positive value is an improvement for TMT-A, PANSS positive, negative, general, DASS depression, anxiety, stress and SQLS total.

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