Figure 3 | Molecular Psychiatry

Figure 3

From: CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies

Figure 3

(a) Frequency distribution of Sp1-binding affinities to the overall core promoter (SpI-III) relative to compartment of origin. (b) Correlation of Sp1 binding to the complete core promoter and basal and Tat-activated transcriptional activity in SVG astrocyte cells (bI and bII) and Jurkat T cells (bIII and bIV). Blue symbols represent CNS-derived LTRs; red symbols represent lymphoid-derived LTRs. Shown are the means. Correlations were calculated using linear regression analysis in Prism 6.0e (GraphPad) with P and r2 values shown. CNS, central nervous system; LTR, long terminal repeat.

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