Figure 1

Coronal brain slices showing the location of the center of all active electrode cathodes, as well as the stimulated area, during the crossover ON phase (17 patients). Contacts are depicted with different symbols, according to the patient’s Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) improvement during the ON phase (vs OFF): ●, <25% improvement; ▴, 25–35%; ▪, 35–65% and ★, >65% improvement. For each patient, the stimulated volume was calculated (see Supplementary Table S3) and indicated by the colored radii extending from the contacts (the radius is only shown on the slice containing the center of the contact, although it may extend over adjacent slices). Note that some patients were stimulated with more than one contact, for example, the three contacts shown on the slice at −15.0 mm are from one patient, as indicated by the extent and shape of the stimulated volume. In the top left corner of each slice, the position anterior (−) or posterior (+) to the anterior commissure is specified. Instead of showing complete coronal slices, a detailed window is shown, dorsally bordered by the corpus callosum and ventrally extending 10 mm below the intercommissural plane, as indicated in the bottom left panel. Additionally, a sagittal view of the brain with indication of the relevant coronal slices is shown. 3 V, third ventricle; ac, anterior commissure; Ac, nucleus accumbens; ALIC, anterior limb of the internal capsule; BST, bed nucleus of the stria terminalis; cc, corpus callosum; Cd, caudate nucleus; DPeH, dorsal periventricular hypothalamic nucleus; EGP, external globus pallidus; FCd, fundus region of caudate nucleus; FLV, frontal horn of lateral ventricle; FPu, fundus region of putamen; fx, fornix; gcc, genu of the corpus callosum; GTI, great terminal island; IC, internal capsule; LH, lateral hypothalamic area; lml, lateral medullary lamina of globus pallidus; LS, lateral septal nucleus; LV, lateral ventricle; mml, medial medullary lamina of globus pallidus; MPO, medial preoptic nucleus; OlfA, olfactory area; Pa, paraventricular nucleus; PRt, prereticular zone; Pu, putamen; SCGP, supracapsular part of globus pallidus; st, stria terminalis. Images are adapted from Mai’s Atlas of the Human Brain.⁴¹

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