Table 1 Burden and type of CNVs >500 kb in cases and controls from each study

CNV sample	CNVs	Number of CNVs				Number of deletions				Number of duplications
		ADHD cases	Controls	Ratio	P	ADHD cases	Controls	Ratio	P	ADHD cases	Controls	Ratio	P
Canada¹¹	N	22	217	0.97	0.88	4	52	0.73	0.55	18	165	1.04	0.87
	Rate	0.089	0.092			0.016	0.022			0.073	0.070
Cardiff^{9, 17}	N	65	78	1.45	0.021	13	13	1.74	0.15	52	65	1.39	0.066
	Rate	0.108	0.074			0.022	0.012			0.086	0.062
CHOP⁸	N	220	382	2.33	4.7 × 10⁻²⁸	28	80	1.42	0.11	192	302	2.58	4.4 × 10⁻²⁹
	Rate	0.217	0.093			0.028	0.019			0.190	0.074
IMAGE 2 (refs 10, 16)	N	89	191	1.28	0.042	22	47	1.29	0.32	67	144	1.28	0.084
	Rate	0.122	0.095			0.030	0.023			0.092	0.072
PUWMa²⁶	N	59	86	1.09	0.59	25	28	1.42	0.19	34	58	0.93	0.74
	Rate	0.085	0.078			0.036	0.025			0.049	0.053

Abbreviations: ADHD, attention-deficit hyperactivity disorder; CHOP, Children's Hospital of Philadelphia; CNV, copy number variant; IMAGE, International Multi-Center ADHD Genetics; PUWMa, Pfizer-funded study from UCLA, Washington University and Massachusetts General Hospital.
N: the number of CNVs observed in the sample; rate: the average number of CNVs per person.

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