Table 2 Enrichment of ADHD case CNV hits in genes containing schizophrenia and autism de novo SNVs (non-synonymous and loss-of-function)

From: Psychiatric gene discoveries shape evidence on ADHD’s biology

Gene set

a Genes

CNVs >500 kb

  

P

P (minus best)b

P (del)

P (dup)

SCZ (NS)

611

5.4 × 10−4

0.015

0.37

5.6 × 10−4

SCZ (LoF)

87

0.33

0.40

0.50

0.27

AUT (NS)

2726

0.019

0.054

0.31

0.024

AUT (LoF)

538

0.026

0.54

0.16

0.072

  1. Abbreviations: ADHD, attention-deficit hyperactivity disorder; AUT, autism; CNV, copy number variant; Del, deletion; Dup, duplication; LoF, loss of function; NS, non-synonymous; SCZ, schizophrenia; SNV, single-nucleotide variant.
  2. aNumber.
  3. bP-value for pathway enrichment after omitting the most significant sample.
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