Table 4 Top pathways in pooled meta-analysis with most significant enrichment for ADHD case CNV hits among CNVs >500 kb
From: Psychiatric gene discoveries shape evidence on ADHD’s biology
Pathway name | Pathway ID | # Genes | P | q-value | P (minus best)a |
|---|---|---|---|---|---|
IL6-mediated signalling events | NCI:62 | 82 | 1.33 × 10−11 | 9.17 × 10−8 | 0.256 |
TGF-β receptor signalling | NCI:95 | 44 | 4.90 × 10−11 | 1.69 × 10−7 | 0.508 |
Defence response to virus | GO:51607 | 147 | 7.02 × 10−8 | 1.62 × 10−4 | 0.31 |
Respiratory electron transport | REACT:1019 | 81 | 1.98 × 10 −7 | 3.41 × 10 −4 | 0.02 |
Organonitrogen compound catabolic process | GO:1901565 | 893 | 9.08 × 10 −7 | 1.05 × 10 −3 | 3.13 × 10 −5 |
Transmembrane transporter activity | GO:22857 | 902 | 9.10 × 10 −7 | 1.05 × 10 −3 | 8.85 × 10 −4 |
Citric acid (TCA) cycle and respiratory electron transport | REACT:1240 | 118 | 1.16 × 10−6 | 1.15 × 10−3 | 0.057 |
Carbohydrate derivative catabolic process | GO:1901136 | 747 | 2.19 × 10 −6 | 1.61 × 10 −3 | 3.34 × 10 −4 |
Ligand-gated ion channel activity | GO:15276 | 136 | 2.33 × 10 −6 | 1.61 × 10 −3 | 3.41 × 10 −4 |
Methyltransferase activity | GO:8168 | 201 | 3.19 × 10 −6 | 2.00 × 10 −3 | 0.022 |
Small thymus | MGI:706 | 199 | 4.15−10−6 | 2.39 × 10−3 | 0.488 |
Transmembrane transport | GO:55085 | 1124 | 5.22 × 10 −6 | 2.44 × 10 −3 | 0.0028 |
Ion-gated channel activity | GO:22839 | 300 | 5.29 × 10 −6 | 2.44 × 10 −3 | 4.18 × 10 −4 |
