Table 1 Demographic, clinical and inflammatory variables of the study sample and their relationship to the primary variable of inflammation (plasma CRP)

From: Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression

Variable

Mean (s.d.) (n=48)

Association with CRP (R)

P-valuea

Demographic

 Age (years)

38.3 (10.9)

−0.12

0.400

 Sex, Male (n, %)

14 (29.2)

0.17

0.236

Race

 Caucasian (n, %)

18 (37.5)

−0.10

0.482

 African American (n, %)

30 (62.5)

  

Smoking status, yes (n, %)

8 (16.7)

−0.06

0.641

BMI (kg m−2)

31.2 (7.6)

0.64

<0.001***

Clinical

 HAM-D Depression Score

23.2 (3.2)

0.25

0.091

 IDS-SR Anhedonia Score

4.8 (1.9)

0.34

0.020*

 SHAPS Score

5.6 (3.0)

0.26

0.073

 Finger Tapping Test, Dominant Hand (mean number taps/10 s)

40.0 (9.9)

−0.29

0.049*

 Trail Making Test A (s)

32.6 (14.5)

0.27

0.066

Inflammatory

 CRP (mg l−1)

2.2 (2.4)

NA

NA

 IL-6 (pg ml−1)

1.61 (1.07)

0.55

<0.001***

 TNF (pg ml−1)

5.52 (2.23)

0.06

0.708

 IL-1beta (pg ml−1)

0.42 (0.23)

0.17

0.249

 IL-6sr (ng ml−1)

15.75 (3.45)

0.16

0.268

 sTNFR2 (ng ml−1)

2.50 (0.89)

0.09

0.554

 IL-1ra (ng ml−1)

1.61 (2.22)

0.41

0.004**

  1. Abbreviations: BMI, body mass index; CRP, C-reactive protein; HAM-D, Hamilton Depression Rating Scale; IDS-SR, Inventory of Depressive Symptomatology, Self-Report; IL, interleukin; IL-1ra, IL-1 receptor antagonist; IL-6sr, IL-6 soluble receptor; NA, not applicable; SHAPS, Snaith–Hamilton Pleasure Scale; sTNFR2, soluble tumor necrosis factor receptor 2. *P<0.05, **P<0.01, ***P<0.001.
  2. aP-value for the correlation with CRP.
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