Table 3 Connectivity between ventral and dorsal striatum and vmPFC predicted anhedonia, motor and psychomotor processing speed

From: Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression

Behavioral assessment

Functional connectivity (Z-scores)

Adjusted R

Adjusted P-value

Anhedonia: Subscale from IDS-SR

Left iVS to vmPFC

−0.47

0.001**

Anhedonia: SHAPS scores

Right vrP to vmPFC

−0.30

0.039*

Motor speed: Finger Tapping Test, Dominant Hand (mean taps per trial)

Right dcP to vmPFC

0.45

0.002**

Psychomotor processing time: Trail Making Test A (s)

Right dC to vmPFC

−0.35

0.015*

  1. Abbreviations: dC, dorsal caudate; dcP, dorsal caudal putamen; IDS-SR, Inventory of Depressive Symptomatology, Self-Report; iVS, inferior ventral striatum; SHAPS, Snaith–Hamilton Pleasure Scale; vmPFC, ventromedial prefrontal cortex; vrP, ventral rostral putamen. Functional connectivity between the indicated brain regions significantly predicted motivational and motor behavior in linear regression models that included age, sex, race, body mass index, smoking status and C-reactive protein. *P<0.05; **P<0.01.
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