Table 2 OR and 95% CI of maternal PCOS and autism spectrum disorders in birth cohorts 1984–2007 in the Swedish population

From: Maternal polycystic ovary syndrome and the risk of autism spectrum disorders in the offspring: a population-based nationwide study in Sweden

 

Full cohort

Subset with BMI data

 

No PCOS

Maternal PCOS

No PCOS

Maternal PCOS

N cases (%)

23 579 (99.3)

169 (0.7)

16 255 (99.3)

122 (0.7)

N controls (%)

207 959 (99.6)

837 (0.4)

116 729 (99.5)

550 (0.5)

OR Model 1 (CI)a

Ref.

1.78 (1.5–2.1)

Ref.

1.64 (1.3–2.0)

OR Model 2 (CI)b

Ref.

1.59 (1.34–1.88)

Ref.

1.45 (1.18–1.78)

OR Model 3 (CI)c

Ref.

1.56 (1.31–1.85)

Ref.

1.41 (1.15–1.73)

OR Model 4 (CI)d

—

—

Ref.

1.34 (1.10–1.65)

OR Model 5 (CI)e

—

—

Ref.

1.32 (1.08–1.62)

  1. Abbreviations: BMI, body mass index; CI, confidence interval; OR, odds ratio; PCOS, polycystic ovary syndrome.
  2. aModel 1: unadjusted.
  3. bModel 2: adjusted for maternal age, paternal age, parental psychiatric history, household income, parental education and mother’s country of birth.
  4. cModel 3: adjusted as above, with further adjustment for obstetric complications (gestational diabetes, Apgar score at 5 min, gestational age, size for gestational age and pre-eclampsia).
  5. dModel 4: Model 2, further adjusted for BMI.
  6. eModel 5: Model 3, further adjusted for BMI.
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