Figure 4
Overview of the proposed sorting nexin 7 (SNX7)-mediated induction of the kynurenine pathway in bipolar disorder (BD). Downregulation of SNX7 induces the degradation of the short form of c-FLIP that competitively inhibits the autocatalytic processing of pro-caspase-8 at the ripoptosome. This leads to increased levels of active caspase-8, resulting in the processing and secretion of interleukin-1β (IL-1β). IL-1β subsequently induces the rate-limiting enzyme tryptophan 2,3-dioxygenase-2 (TDO2) in the kynurenine pathway, causing an elevation in brain kynurenic acid (KYNA) that, according to our clinical association data, leads to a persistent set-shifting impairment as well as to a dopaminergic dysregulation that evoke vulnerability for psychosis in bipolar disorder.
