Table 3 Age-, sex- and population stratification-adjusted univariate and bivariate GCTA-derived and LDSC-derived estimates

From: Assessing the genetic overlap between BMI and cognitive function

Univariate estimates

n

est a

s.e.

General cognitive function

 Same-sample GCTA

6273

0.29

0.06

 Independent-samples GCTA

6985

0.31

0.05

 LDSC

48 462

0.15

0.01

BMI

 Same-sample GCTA

6463

0.28

0.06

 Independent-samples GCTA

20 806

0.22

0.02

 LDSC

339 224

0.14

0.01

Bivariate estimates

N

rG

s.e.

Same-sample GCTA

6273:6463

−0.51

0.15

Independent-samples GCTA

6985:20 806

−0.10

0.08

LDSC

48 462:339 224

−0.22

0.03

  1. Abbreviations: BMI, body mass index; GCTA, genome-wide complex trait analysis; LDSC, Linkage Disequilibrium Score Regression; rG, genetic correlation.
  2. aThe proportion of variance in the phenotype explained by common genetic variants.
Back to article page