Figure 2

(a) Cohen's d-effect sizes 95% CI for differences in subcortical brain volumes between recurrent major depressive disorder (MDD) patients and healthy control subjects (striped pattern) and between first episode MDD patients and healthy controls (no pattern). (b) Cohen's d-effect sizes 95% CI for differences in subcortical brain volumes between early onset (⩽21) MDD patients and healthy control subjects (no pattern) and between later onset (>21) MDD patients and healthy controls (striped pattern). Effect sizes were corrected for age, sex and intracranial volume (ICV). *P<0.05 corrected, **P<0.05. CI, confidence interval.