Table 1 Full meta-analytic results for each mean structure for the MDD patients versus controls comparison controlling for age, sex, scan center and ICV

	Cohen's d ^a (MDD—CTL)	Standard error	95% CI	% Difference	P-value	I ²	Number of controls	Number of patients
Lateral ventricles	0.056	0.037	−0.017–0.129	1.345	0.130	12.162	7058	1689
Thalamus	−0.044	0.038	−0.119–0.031	−0.398	0.250	15.067	7046	1682
Caudate	−0.023	0.050	−0.121–0.074	−0.232	0.641	45.729	7034	1681
Putamen	0.012	0.034	−0.054–0.078	0.104	0.722	0.005	6957	1656
Pallidum	−0.001	0.034	−0.067–0.065	−0.049	0.972	0.000	7018	1657
Hippocampus	−0.144	0.041	−0.225 to −0.064	−1.245	4.60 × 10⁻⁴	24.813	7040	1700
Amygdala	−0.060	0.036	−0.132–0.011	−0.658	0.097	10.152	7060	1696
Accumbens	−0.019	0.034	−0.085–0.047	−0.203	0.569	0.000	6967	1652
ICV	−0.029	0.052	−0.131–0.073	−0.212	0.575	51.476	7199	1728

Abbreviations: CI, confidence intervals; CTL, control; ICV, intracranial volume; MDD, major depressive disorder.
^aIncluded samples: all samples.
Adjusted Cohen's d is reported.

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