Figure 2
Characterization of the behavioral deficit induced by ketamine (a) Learning curves. Curves show percentage of correct response average across blocks, cues and bins of 10 consecutive trials, for the placebo (blue) and ketamine (red) sessions, separately. There was a significant effect of drug status in the last trial bin, with higher performance with placebo. Bold lines represent means; color-delimited areas represent inter-subject s.e.m (corrected for the variance across subject: the grand mean of each subject was removed from its data before computing s.e.m.). (b) Parameter estimates for the best computational model. The only parameter that significantly differed between sessions (placebo in blue versus ketamine in red) was κ, the weight that confidence had on learning rate and choice temperature. α0: learning rate value when confidence=0; β0: choice temperature value when confidence=0; C0: initial confidence value; γ: confidence learning rate. Bars represent means; error bars represent inter-subject s.e.m (corrected for the variance across subject: the grand mean of each subject was removed from its data before computing s.e.m.); *P<0.05, two-tailed paired t-test.
