Table 3 Results of replication studies for R336C

From: A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences

Sample

P-value

OR

N cases

AF cases

N ctrls

AF ctrls

Carriers

       

Cases

Ctrls

LC

 The Netherlands

0.32

3.7

634

7.9 × 10−4

4670

2.1 × 10−4

1

2

 Spain

1

0

455

0

1444

3.5 × 10−4

0

1

 USA

0.10

8.2

195

5.1 × 10−3

798

6.3 × 10−4

2

1

 Norway

—

—

426

0

758

0

0

0

 All LC

0.098

3.8

1710

—

7670

—

  

COPD

 UK

1

1.6

206

2.4 x 10−3

338

1.5 × 10−3

1

1

 Sweden

—

—

581

0

918

0

0

0

 Denmark

1

0

708

0

924

5.4 × 10−4

0

1

 All COPD

1

0.8

1495

—

2180

—

  
  1. Abbreviations: COPD, chronic obstructive pulmonary disease; LC, lung cancer; OR, odds ratio.
  2. Table 3 shows the results from replication studies of the R336C in populations outside of Iceland. Listed are for each sample set: P-value, OR, number of cases and controls (N cases and N ctrls), allele frequencies (AF cases and AF ctrls) and the number of observed carriers for cases and controls.
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