Figure 6
Lentiviral-mediated knockdown of Prdm2 in the dmPFC alters addiction-like behaviors (a–c): Voluntary alcohol-self-administration (a) (One way ANOVA: main effect of group; scrambled versus PRDM2 rats; F(1,40)=5.9; P<0.02), compulsive drinking in a quinine adulteration task (b) (Repeated-measure ANOVA: main effect of group; Scrambled versus PRDM2 rats; F(1,48)=7; P=0.02), and stress-induced relapse (c) (Repeated-measure ANOVA; main effect of group; scrambled versus PRDM2 rats F(1,84)=9.3; P=0.006). Lentiviral knockdown of Prdm2 did not affect control behaviors (d–h) such as locomotor activity (d), average velocity (e), sensitivity to shock intensity (f), sucrose self-administration (g), nor rat weight (h). The mean values (±s.e.m.) of scrambled rats are shown in black bars. The mean values (±s.e.m.) of PRDM2 knockdown rats are shown in gray bars (n=9–10). *p<0.05, scrambled versus PRDM2 rats.
