Table 2 GO functional enrichment analysis of 119 overlapping genes implicated in H3K9me1 ChIP-seq and RNA-seq analysis of post-dependent rat dmPFC.

From: Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2

Category

GO

GO ID

Number of hit genes versus expected number

Ratio of enrichment

P-value

Cellular component

Coated vesicle

GO:0030135

6/1.33

4.51

0.00005

 

Dendrite

GO:0030425

8/2.77

2.89

0.0001

 

Cell junction

GO:0030054

11/4.10

2.69

0.0002

 

Golgi apparatus part

GO:0044431

7/2.26

3.10

0.0002

 

Voltage-gated calcium channel complex

GO:0005891

2/0.15

13.67

0.0002

 

Golgi stack

GO:0005795

4/0.56

7.15

0.0003

 

Neuron projection

GO:0043005

14/5.21

2.69

0.0004

 

Organelle subcompartment

GO:0031984

3/0.41

7.37

0.0004

 

Excitatory synapse

GO:0060076

2/0.15

13.10

0.0004

 

Trans-Golgi network transport vesicle

GO:0030140

2/0.13

14.98

0.0004

Molecular function

Methylcytosine dioxygenase activity

GO:0070579

2/0.03

75.32

0.0003

 

SH3 domain binding

GO:0017124

5/0.64

7.85

0.0004

 

Calcium ion transmembrane transporter activity

GO:0015085

5/0.64

7.76

0.0005

 

Calcium:cation antiporter activity

GO:0015368

2/0.05

43.04

0.0009

 

Divalent inorganic cation transmembrane transporter activity

GO:0072509

5/0.82

6.12

0.0014

 

Protein domain-specific binding

GO:0019904

11/3.79

2.90

0.0014

 

Calcium channel activity

GO:0005262

4/0.54

7.44

0.0021

 

Inositol phosphate phosphatase activity

GO:0052745

2/0.09

23.17

0.0032

 

Phosphatase activity

GO:0016791

6/1.53

3.91

0.0044

 

Voltage-gated channel activity

GO:0022832

5/1.10

4.54

0.0050

Biological process

Glomerulus vasculature morphogenesis

GO:0072103

2/0.03

60.85

0.0007

 

Positive regulation of smooth muscle cell proliferation

GO:0048661

5/0.39

12.68

0.0022

 

Artery development

GO:0060840

4/0.34

11.93

0.0024

 

Aorta morphogenesis

GO:0035909

3/0.11

26.84

0.0026

 

Regulation of smooth muscle cell migration

GO:0014910

4/0.26

15.60

0.0065

 

Muscle cell migration

GO:0014812

4/0.30

13.23

0.0075

 

Comma-shaped body morphogenesis

GO:0072049

2/0.03

60.85

0.0078

 

Regulation of smooth muscle cell proliferation

GO:0048660

5/0.63

7.92

0.0078

 

Artery morphogenesis

GO:0048844

4/0.28

14.15

0.0093

 

Negative regulation of chromatin silencing

GO:0031936

2/0.03

60.85

0.0101

  1. Abbreviations: dmPFC, dorsomedial prefrontal cortex; GO, gene ontology; H3K9me1, histone 3 at the lysine 9 residue; RNA-seq, RNA-sequencing.
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