Figure 2
From: The PHF21B gene is associated with major depression and modulates the stress response
Manhattan plots for a GWAS of major depressive disorder (MDD) in a cohort of Mexican-American patients (n=203) and matched controls (n=196). Results of the GWAS using an additive model after correcting stratification by principal component analysis. In the inset, the first and second principal components that shows absence of genetic stratification (left box), and the Q–Q plot of observed vs expected of the −log10 (P-values, right box). The estimated Genomic Control ‘inflation factor’ λ was 1. GWAS, genome-wide association study.
