Table 1A Genome-wide variants significantly associated with major depressive disorder
From: The PHF21B gene is associated with major depression and modulates the stress response
SNP | Chr | rs ID | Gene | Major allele | P-value | P-value FDR | Minor allele freq. (cases) | Minor allele freq. (controls) | HGVS coding 1 | HGVS protein |
|---|---|---|---|---|---|---|---|---|---|---|
exm167893 | 1 | rs41310573 | OR2T12 | T | 4.39E−20 | 3.59E−15 | 0.30 | 0.07 | c.115A>G | p.Ser39Gly |
exm1508600 | 19 | rs201935337 | TMEM150B | C | 4.77E−11 | 1.95E−6 | 0.10 | 0.00 | c.136G>A | p.Gly46Arg |
exm1616604 | 22 | rs140395831 | PRR5-ARHGAP8 | A | 3.01E−10 | 6.16E−6 | 0.09 | 0.00 | c.1252A>C | p.Ser418Arg |
exm875366 | 11 | rs56293203 | MUC5B | G | 1.57E−9 | 2.57E−5 | 0.13 | 0.02 | c.442G>A | p.Val148Ile |
exm283068 | 2 | rs78562453 | C2orf54 | C | 6.23E−8 | 7.28E−4 | 0.06 | 0.00 | c.36G>C | p.Arg12Ser |
exm445797 | 5 | rs115054458 | TRIO | C | 3.43E−7 | 3.51E−3 | 0.08 | 0.01 | c.7391C>T | p.Ala2464Val |
exm1441979 | 19 | rs143696449 | ANO8 | G | 4.55E−7 | 4.13E−3 | 0.06 | 0.00 | c.3206C>T | p.Ala1069Val |
exm669085 | 7 | rs748441912 | KRBA1 | A | 4.94E−7 | 4.04E−3 | 0.11 | 0.02 | c.2535G>A | Synonymous |
exm75804 | 1 | rs62001028 | BCAR3 | G | 5.32E−7 | 3.96E−3 | 0.07 | 0.00 | c.820C>T | p.Arg274Trp |
exm1355772 | 17 | rs150952348 | UNC13D | T | 6.71E−7 | 4.57E−3 | 0.06 | 0.00 | c.3160A>G | p.Ile1054Val |
exm1044842 | 12 | Rs782472239 | ORAI1 | C | 9.12E−7 | 5.74E−3 | 0.08 | 0.00 | c.638C>A | p.Pro213His |
exm1435859 | 19 | rs112610420 | EMR2 | T | 1.22E−6 | 7.15E−3 | 0.07 | 0.00 | c.875A>C | p.Tyr292Ser |
exm1325307 | 17 | rs142029931 | CNTNAP1 | G | 1.31E−6 | 7.16E−3 | 0.06 | 0.00 | c.2501G>A | p.Arg834His |
exm1505393 | 19 | rs201483250 | LILRA1 | C | 1.48E−6 | 7.55E−3 | 0.17 | 0.06 | c.535C>T | p.Arg179Trp |
exm1369092 | 17 | rs200897153 | FASN | C | 2.49E−6 | 0.01 | 0.10 | 0.01 | c.5801G>A | p.Arg1934His |
exm1293569 | 17 | rs3744550 | MYH13 | T | 3.57E−6 | 0.02 | 0.30 | 0.15 | c.5585A>G | p.His1862Arg |
exm782507 | 9 | rs115668237 | SLC2A8 | C | 5.87E−6 | 0.03 | 0.04 | 0.00 | c.1239C>G | p.Cys413Trp |
exm2249659 | 11 | rs56344012 | MUC5B | A | 1.04E−5 | 0.04 | 0.07 | 0.01 | c.15861A>G | Synonymous |
exm2275308 | 19 | rs200520741 | HOMER3 | C | 1.05E−5 | 0.04 | 0.05 | 0.00 | Splicing | Splicing |
