Table 3 Whole-genome sequencing analysis of 25 human samples
From: The PHF21B gene is associated with major depression and modulates the stress response
Sample | Total SNVs | Total INDELS | Total variations | dbSNP | dbSNP% | Exonic | Synonyms | Non-synonyms | Intronic |
|---|---|---|---|---|---|---|---|---|---|
AU mean (n=10) | 390 1078 | 546 756.6 | 4 447 834.6 | 3 900 468.9 | 87.7 | 23 942.4 | 12 613.4 | 11 329 | 1 318 630 |
AU SD (n=10) | 37083.5 | 35237.0 | 67382.1 | 51576.2 | 0.4 | 291.1 | 142.3 | 177.9 | 8851.6 |
MA mean (n=15) | 772 9021.3 | 517 554.1 | 8 246 575.4 | 3 995 923.3 | 48.6 | 114 430.9 | 31 641.7 | 82 789.1 | 2 927 921 |
MA SD (n=15) | 413 339 | 5041.5 | 412 190.9 | 43 721.7 | 2.7 | 7998.5 | 1800.7 | 6263 | 179 407.6 |
T-test, P | 2.09E−15 | 0.028 | 7.05E−16 | 0.00016 | 7.22E−19 | 1.99E−16 | 3.64E−16 | 1.83E−16 | 4.70E−15 |
Mann–Whitney U, P | 3.59E−05 | 9.65E−04 | 3.59E−05 | 5.27E−04 | 3.59E−05 | 3.59E−05 | 3.59E−05 | 3.59E−05 | 3.59E−05 |
Sample | Intergenic | Splicing | 3′ UTR3 | 5′ UTR | Down-stream | Up-stream | ncRNA exonic | ncRNA intronic | ncRNA splicing |
|---|---|---|---|---|---|---|---|---|---|
AU mean (n=10) | 2 246 762 | 111.5 | 25 759.4 | 5859.9 | 25 626.1 | 25 116 | 12 966.1 | 217 112.9 | 71.4 |
AU SD (n=10) | 25 571.3 | 8.6 | 176.9 | 68.6 | 360.3 | 324.1 | 150.1 | 3070.5 | 5.3 |
MA mean (n=15) | 4 015 894 | 5630.7 | 66 925.8 | 28 831.7 | 63 537.3 | 82 268.7 | 29 111.9 | 397 645.2 | 338.1 |
MA SD (n=15) | 198 644.7 | 287.1 | 4324.0 | 5222.3 | 4372.6 | 5407.0 | 1497.9 | 19 516.4 | 22.1 |
T-test, P | 2.16E−15 | 1.24E−19 | 2.15E−15 | 9.28E−11 | 5.76E−15 | 4.37E−16 | 2.11E−16 | 7.52E−16 | 1.61E−18 |
Mann–Whitney U, P | 3.59E−05 | 3.58E−05 | 3.59E−05 | 3.59E−05 | 3.59E−05 | 3.59E−05 | 3.59E−05 | 3.59E−05 | 3.53E−05 |
