Figure 4
From: The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior
Genetic disruption of the PGN recognition protein 2 alters the expression of synapse-related genes and social behavior. Gene expression levels of c-Met (a), Bdnf (b) and Syp (c) in the prefrontal cortex and striatum of 3-day-old Pglyrp2 knockout (KO) and wild-type (WT) male and female mice (n=5 for male Pglyrp2 KO mice, n=6 for female Pglyrp2 KO mice and n=6 for WT mice). Bars show time (seconds) spent in the different chambers during the social approach session by Pglyrp2 KO and WT male (d) and female (g) mice (n=8 per group). Bars show time (seconds) spent interacting with the stimulus mouse or in close proximity to the novel object by male (e) and female (h) mice. Representative traces of movement patterns of Pglyrp2 KO (dark green) and WT (light green) male (f) and female (i) mice during the 10-min sociability test. All data (a–e, g and h) are presented as means (±s.e.m.). *P<0.05, **P<0.01 compared with their respective WT mice. PGN, peptidoglycan.
