Figure 1

Biphasic effects of JZL184 on immobility of acutely stressed mice (a) an intraperitoneal (i.p.) injection of 5 or 20 mg kg⁻¹ of JZL184 respectively decreases and increases immobility. (b) AM281 dose-dependently decreases immobility. (c–f) An i.p. injection of AM281 (0.3 mg kg⁻¹) (c,d) or Tat-GluR2 (e) and an intra-CA1 injection of Tat-GluR2 (f) abolish the decreased immobility produced by JZL184 (5 mg kg⁻¹, i.p.). (g) Muscimol and JZL184 (20 mg kg⁻¹) together decrease immobility. (h) Tat-GluR2 and muscimol together abolish the increased immobility produced by 20 mg kg⁻¹ JZL184. All summary graphs show means±s.e.m.; n=numbers of animals recorded in each group. *P<0.05 and **P<0.01 vs control, LSD post-hoc test after one-way ANOVA (a: F_4,51=10.173, P<0.01; b: F_3,42=12.573, P<0.01; c: F_3,40=12.098, P<0.01; d: F_3,40=9.817, P<0.01; e: F_4,51=9.212, P<0.01; f: F_2,32=13.189, P<0.01; g: F_3,40=20.173, P<0.01; h: F_3,42=9.107, P<0.01).

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