Figure 1
From: Schizophrenia copy number variants and associative learning
Extinction-related genes are enriched in copy number variants (CNVs) from patients with schizophrenia. (a) The top 5% genes differentially expressed following fear extinction (Supplementary Table 3), but not consolidation (Consol) or retrieval, are overrepresented in schizophrenia CNVs vs control CNVs (P=3.9 × 10−4). Bars represent −log10(P-value) after logistic regression enrichment analysis and Bonferroni P-value correction. (b) Deletions from schizophrenic patients alone show an overrepresentation of fear extinction-related genes (P=0.0034, Bonferroni corrected). (c) The enrichment of fear extinction-related genes in duplications from schizophrenic patients is significant (P=0.042, Bonferroni corrected) yet weaker than in deletions. (d–f) Enrichment analyses performed over the top 1, 2, 5, 10, 15, 20 and 25% genes associated with consolidation, retrieval and extinction of fear memory. Points represent −log10(P-value) × sgn(Z-value) where P is empirically determined from permutation correction (Supplementary Figure 1). For (a–f), dotted lines represent a P=0.05 threshold for statistical significance.
