Table 2A Genome-wide significant index SNPs. Combined meta-analysis of UK Biobank, GS:SFHS and QIMR data sets

From: Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci

Index SNP

Chr

Position

A1/A2

Freq

β (s.e.)

P

Direction (UKBB-GS-QMIR)

Heter P

Associated region

Genes

rs490647

1

37 242 743

A/G

0.227

0.092 (0.017)

3.8 × 10−8

+++

0.577

37 219 429–37 261 085

GRIK3

rs4653663

1

225 927 218

A/T

0.255

0.091 (0.016)

2.0 × 10−8

+++

0.097

225 899 639–225 947 638

ENAH, SRP9

rs12637928

3

110 184 749

A/T

0.490

−0.077 (0.014)

4.3 × 10−8

−−−

0.663

110 103 126–110 299 632

PVRL3 (579KB distal)

rs62353264

4

166 085 805

A/T

0.986

−0.335 (0.061)

3.7 × 10−8

−−+

0.261

166 063 134–166 198 156

TMEM192, KLHL2, MSMO1

rs12682352

8

8 646 246

T/C

0.525

0.115 (0.014)

1.5 × 10−15

+++

0.366

8 301 794–10 831 868

More than 10 genes

rs12378446

9

11 369 213

T/C

0.791

0.100 (0.017)

9.4 × 10−9

+++

0.919

11 131 371–11 880 898

PTRD (650KB distal)

rs4977844

9

23 295 899

C/G

0.358

0.083 (0.015)

3.2 × 10−8

+++

0.367

23 291 526–23 340 616

ELAVL2

rs111433752

17

43 857 989

T/G

0.790

−0.120 (0.018)

9.3 × 10−12

−−−

0.068

43 463 493–44 865 603

More than 10 genes

rs1187264

18

35 289 647

C/G

0.136

0.118 (0.021)

1.2 × 10−8

+++

0.526

35 287 090–35 413 260

CELF4

  1. Abbreviations: Chr, chromosome; Freq, frequency; GS:SFHS, Generation Scotland: Scottish Family Health Study; Heter, heterogeneity; QIMR, Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute; SNP, single-nucleotide polymorphism.
  2. Shown are linkage disequilibrium (LD)-independent genome-wide significant SNP associations for neuroticism (sorted by genomic position according to UCSC hg19/NCBI Build 37). Column A1/A2 has the SNP alleles, with the first allele (A1) the reference allele for the frequency and β columns. Frequency of allele 1 is calculated in the UK BioBank data set. Chr and Position denote the location of the index SNP. β Is linear regression coefficient for allele1, and s.e. is the standard error for β. Associated region indicates range positions of SNPs with r2 >0.6 with the index and any other genome-wide association study (GWAS) significant SNP at the locus. The final column indicates protein-coding reference sequence genes at the associated loci (see region plots in Supplementary Information) or where there are no genes at the associated locus, the nearest gene if <1 Mb from the locus.
Back to article page