Table 3 Genetic correlations between neuroticism and MDD, schizophrenia and bipolar disorder

From: Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci

 

N cases

N controls

Genetic correlation

s.e. genetic correlation

Significance (P-value)

MDD

9240

9519

0.64

0.07

3.31 × 10−19

Bipolar disorder

7481

9250

0.07

0.05

0.1505

Schizophrenia

34 241

45 604

0.22

0.05

1.96 × 10−5

  1. Abbreviation: MDD, major depressive disorder.
  2. Columns ‘N cases’ and ‘N controls’ show the numbers of cases and controls in the corresponding PGC2 genome-wide association studies (https://www.med.unc.edu/pgc/downloads). Columns 4–6 present genetic correlation estimates, their s.e. and significance, respectively, calculated with linkage disequilibrium (LD) score regression tool (https://github.com/bulik/ldsc).
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