Figure 3
Deficient working memory and normal long-term spatial memory, long-term synaptic plasticity and acoustic startle in Mrpl40+/− mice. (a, b) Mean maximal startle responses as a function of sound intensity (a) and prepulse inhibition (PPI) (b) in Mrpl40+/− and wild-type (WT) littermates. (c) The mean numbers of correct choices made in the delayed non-matched-to-position task by Mrpl40+/− and WT littermates. (d–f) Morris water maze tasks. Average time to find a submerged platform during the learning phase (d), time spent in quadrants during the probe test performed 48 h after the last learning session (e) and time to travel to a visible platform (f) in Mrpl40+/− and WT littermates. Abbreviations: AdL, adjacent left quadrant; AdR, adjacent right quadrant; Opp, opposite quadrant; Tg, target quadrant. (g) Average percentage of time spent in the novel arm in the novel-recognition version of the Y-maze task by Mrpl40+/− and WT mice. (h) Long-term potentiation at CA3–CA1 synapses measured as mean field EPSP (fEPSP) as a function of time before and after tetanization of Schaffer collaterals with 200-Hz trains (arrows) in Mrpl40+/− and WT mice. Dashed lines in (c, g) indicate the level of performance expected by chance. Numbers of mice or slices are shown in parentheses or inside columns. *P <0.05.
