Figure 4 | Molecular Psychiatry

Figure 4

From: Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium

Figure 4

The mitochondrial permeability transition pore (mPTP) inhibitor bongkrekic acid (BKA) mimics the short-term potentiation (STP) and calcium transient phenotypes of Df(16)5+/− and Mrpl40+/− mice. (a–f) BKA effect on augmentation (a, d), peak GCaMP6 (b, e) and peak mitoGCaMP6 fluorescence intensities (c, f) in wild-type (WT) and Df(16)5+/− littermates (a–c) or WT and Mrpl40+/− littermates (normalized to WT levels) (d–f). Numbers of neurons or fluorescent puncta are shown inside columns. *P<0.05.

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