Figure 1 | Molecular Psychiatry

Figure 1

From: Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia

Figure 1

Study design and key results. To investigate the association of genetic variants with clozapine-associated neutropenia, we conducted (a) a genome-wide association study (GWAS), (b) human leukocyte antigen (HLA) allele imputation and genotyped a candidate variant of interest, HLA-DQB1 6672G>C/ rs113332494, (c) exome array single variant and gene-based analysis and (d) copy-number variation (CNV) analysis. We then took forward the associated variants from GWAS, HLA and exome array analyses to a combined meta-analysis with the Clozapine-Induced Agranulocytosis Consortium (CIAC) study.

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