Table 2 Exome array meta-analysis top 10 variants
CHR | Variant | rs ID | Position | A1 | CLOZUK P-value | CIAC P-value | Meta-analysis P-value | Gene | Location | Function |
|---|---|---|---|---|---|---|---|---|---|---|
4 | exm387558 | rs201099591 | 7 436 363 | A | 2.48 × 10−3 | 1.31 × 10−4 | 1.10 × 10−6 | PSAPL1, SORCS2 | Exonic, intronic | Missensea |
7 | exm622984 | rs17139320 | 63 726 370 | G | 3.96 × 10−3 | 2.87 × 10−4 | 3.70 × 10−6 | ZNF679 | Exonic | Missensea |
8 | exm729894 | rs201071539 | 145 003 862 | A | 2.19 × 10−3 | 1.69 × 10−3 | 1.19 × 10−5 | PLEC | Exonic | Missensea |
19 | exm1421170 | rs2591594 | 9 076 728 | A | 4.66 × 10−3 | 3.26 × 10−3 | 4.52 × 10−5 | MUC16 | Exonic | Missenseb |
12 | exm988839 | rs1546308 | 21 176 135 | C | 1.25 × 10−4 | 0.0679 | 9.13 × 10−5 | SLCO1B7, SLCO1B3 | Exonic, intronic | Missensea |
1 | exm23767 | rs12073549 | 17 720 545 | T | 1.60 × 10−3 | 0.0163 | 9.31 × 10−5 | PADI6 | Exonic | Synonymous |
15 | exm1186658 | rs117116488 | 89 390 513 | T | 2.76 × 10−4 | 0.0448 | 9.73 × 10−5 | ACAN | Exonic | Missenseb |
12 | exm981950 | rs79149293 | 8 975 873 | G | 5.66 × 10−5 | 0.0967 | 1.01 × 10−4 | A2ML1 | Exonic | Missensec |
12 | exm995289 | rs138912646 | 42 711 606 | A | 3.94 × 10−5 | 0.1613 | 1.79 × 10−4 | ZCRB1, PPHLN1 | Exonic, intronic | Missensea |
12 | exm1051374 | rs143584336 | 130 921 539 | A | 1.22 × 10−4 | 0.1144 | 2.12 × 10−4 | RIMBP2 | Exonic | Missensea |
