Table 2 Association between maternal fever and risk of ASD in offspring, at any time during pregnancy and by trimester

From: Prenatal fever and autism risk

Exposure period

ASD fever-exposed N (%)

Non-case fever-exposed N (%)

Crude model

Adjusted model

   

OR

95% CI

P-value

aOR a

95% CI

P-value

Any time during pregnancyb (N=79 109)

98 (20.68)

13 509 (17.18)

1.26

1.01

1.57

0.045

1.34

1.07

1.67

0.011

First trimesterc (N=95 115)

24 (4.14)

3069 (3.25)

1.29

0.85

1.94

0.229

1.34

0.89

2.02

0.162

Second trimesterd (N=87 648)

85 (16.04)

11 067 (12.70)

1.31

1.04

1.66

0.022

1.40

1.11

1.77

0.005

Third trimestere (N=79 748)

17 (3.56)

2627 (3.31)

1.08

0.66

1.75

0.761

1.15

0.70

1.87

0.583

  1. Abbreviations: aOR, adjusted odds ratio; ASD, autism spectrum disorder; CI, confidence interval; OR, odds ratio.
  2. Key: bold text represents significant findings, P<0.05.
  3. aAdjusted for: maternal age, smoking and parity; parental education and birth year.
  4. bRespondents to all three questionnaires containing prenatal fever data: ASD, N=474; non-case, N=78 635.
  5. cAll respondents to 17-week prenatal questionnaire: ASD, N=580; non-case, N=94 535.
  6. dAll respondents to both the 17- and 30-week prenatal questionnaires: ASD, N=530; non-case, N=87 118.
  7. eAll respondents to both the 30-week prenatal and the 6-month postnatal questionnaires: ASD, N=477; non-case, N=79 271.
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