Table 3 Association between maternal fever and risk of ASD in offspring, by trimester (respondents to Q1, Q3 and Q4; N=79 109a)

From: Prenatal fever and autism risk

Exposure period

ASD fever-exposed N (%)

Non-case fever-exposed N (%)

Crude model

Adjusted models

   

OR

95% CI

P-value

aOR1 b

95% CI

P-value

aOR2 c

95% CI

P-value

aOR3 d

95% CI

P-value

First trimester

20 (4.22)

2 511 (3.19)

1.34

0.85

2.09

0.207

1.27

0.81

2.00

0.299

1.37

0.87

2.15

0.170

1.29

0.82

2.03

0.272

Second trimester

76 (16.03)

9 869 (12.55)

1.33

1.04

1.70

0.023

1.31

1.02

1.68

0.032

1.42

1.11

1.82

0.005

1.40

1.09

1.79

0.008

Third trimester

17 (3.59)

2 606 (3.31)

1.09

0.67

1.76

0.741

1.03

0.63

1.68

0.900

1.15

0.71

1.88

0.566

1.08

0.66

1.77

0.746

  1. Abbreviations: aOR, adjusted odds ratio; ASD, autism spectrum disorder; CI, confidence interval; OR, odds ratio.
  2. Key: bold text represents significant findings, P<0.05.
  3. aASD, N=474; non-case, N=78 635.
  4. baOR1: adjusted for presence of fever in the other trimesters (Adjusted Model 1).
  5. caOR2: adjusted for maternal age, smoking and parity; parental education; and birth year (Adjusted Model 2).
  6. daOR3: adjusted for presence of fever in the other trimesters and confounder variables (maternal age, smoking and parity; parental education; and birth year) (Adjusted Model 3).
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