Table 4 Biological pathways
From: Precision medicine for suicidality: from universality to subtypes and personalization
A. Universal biomarkers | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Universal pathways | DAVID GO functional annotation biological processes | KEGG pathways | Ingenuity pathways | |||||||||
# | Term | Count | % | P-value | Term | Count | % | P-value | Top Canonical Pathways | P-value | Overlap | |
Validation Bonferroni significant (n=130 genes, 148 probe sets) | 1 | Regulation of neurogenesis | 8 | 6.6 | 2.10E−04 | Tryptophan metabolism | 4 | 0.2 | 1.10E−02 | Protein kinase A signaling | 4.36E−06 | 0.031 12/386 |
2 | Negative regulation of apoptosis | 11 | 9 | 2.60E−04 | Neurotrophin signaling pathway | 6 | 0.3 | 1.40E−02 | IGF-1 signaling | 2.86E−05 | 0.062 35/582 | |
3 | Negative regulation of programmed cell death | 11 | 9 | 2.90E−04 | Insulin signaling pathway | 6 | 0.3 | 1.90E−02 | Gap junction signaling | 4.66E−05 | 0.045 7/155 | |
4 | Negative regulation of cell death | 11 | 9 | 3.00E−04 | Butanoate metabolism | 3 | 0.2 | 5.90E−02 | Renin-angiotensin signaling | 5.52E−05 | 0.055 6/109 | |
5 | Regulation of cell morphogenesis | 7 | 5.7 | 3.90E−04 | Endocytosis | 6 | 0.3 | 6.10E−02 | Hepatic cholestasis | 5.93E−05 | 0.043 7/161 | |
B. Male Bipolar biomarkers | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Male bipolar pathways | DAVID GO functional annotation biological processes | KEGG pathways | Ingenuity pathways | |||||||||
Validation Bonferroni significant (n=50 genes, 54 probe sets) | # | Term | Count | % | P-value | Term | Count | % | P-value | Top Canonical Pathways | P-value | Overlap |
1 | Negative regulation of neuron differentiation | 7 | 14.6 | 9.30E−06 | mTOR signaling pathway | 3 | 6.2 | 1.60E−02 | G-protein coupled receptor signaling | 1.14E−14 | 0.113 29/256 | |
2 | Negative regulation of neurogenesis | 7 | 14.6 | 3.60E−05 | Small cell lung cancer | 3 | 6.2 | 3.20E−02 | CREB signaling in neurons | 1.98E−14 | 0.14 24/171 | |
3 | Negative regulation of nervous system development | 7 | 14.6 | 5.50E−05 | Leukocyte transendothelial migration | 3 | 6.2 | 5.80E−02 | Neuropathic pain signaling in dorsal horn neurons | 4.82E−13 | 0.18 18/100 | |
4 | Positive regulation of protein localization to plasma membrane | 4 | 8.3 | 1.10E−04 | Sphingolipid signaling pathway | 3 | 6.2 | 6.00E−02 | 14-3-3-mediated signaling | 7.79E−12 | 0.154 18/117 | |
5 | Positive regulation of protein localization to cell periphery | 4 | 8.3 | 1.10E−04 | NA | NA | NA | NA | Gap junction signaling | 1.50E−11 | 0.129 20/155 | |
