Figure 1

Hippocampal contextual fear memory deficit and increased Dio3 expression in adult fetal alcohol exposure offspring are alleviated by neonatal T4 treatment. (a) Memory deficit was measured as decreased time (in seconds) spent freezing in the second day of contextual fear-conditioning test. Male and female neonates of dams on different diet from gestation day 8 to 21 received either T4 (0.05 μg g⁻¹ per day) or vehicle treatment between postnatal days 1 and 10, and were tested in adulthood (N=16–24 per prenatal diet/neonatal treatment; sex combined). (b) Hippocampal transcript levels of Dio3 were measured by quantitative real-time PCR. N=8–15 per prenatal diet/neonatal treatment. Data represented as mean±s.e.m. **P<0.01, Bonferroni post hoc test within neonatal treatments.