Figure 3 | Molecular Psychiatry

Figure 3

From: Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin

Figure 3

Neonatal metformin treatment reverses fetal alcohol exposure-induced fear memory deficit and hippocampal Igf2 and Grb10 expression in adult offspring. (a) Metformin administration (200 μg g−1 per day, from postnatal day 1 to 10) reversed the fear memory deficit of adult ethanol offspring. N=11–24 per prenatal diet/neonatal treatment; sex combined. Transcript levels of (b) Igf2, male (N=4–11 per prenatal diet/neonatal treatment) and female (N=5–8 per prenatal diet/neonatal treatment), and (c) Grb10 (N=8–13 per prenatal diet/neonatal treatment, sex combined) in the hippocampus of adult offspring. Details are as described in Figure 1. **P<0.01, Bonferroni post hoc test within prenatal treatment groups.

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